Ross Moriarty and Leon Brown both featured as battling Wales ensured they picked up a losing bonus-point at Twickenham as they closed to within three points at the end of another epic battle against the auld enemy.
England led 20-9 at the break, but were hit by a try from the kick-off at the start of the second half as Wayne Pivac’s men got their fight-back off to an explosive start.
Justin Tipuric scored twice after the break, the second try coming when England were down to 13 men.
Having lost replacement prop Ellis Genge to a yellow card, they lost centre Manu Tuilagi to a straight red for a shoulder to the head in a last-ditch tackle to try to stop the Wales wing. Even so, they hung on to clinch the Triple Crown for the 25th time.
Wales are next in action on Saturday (March 14) when they face Scotland at Principality Stadium (kick-off 2.15pm).