Captain Cory Hill is among seven changes to the starting line-up as Dragons head to France to face the Top14 giants who currently top Pool 1 with an undefeated record.
A new-look back row for the Round 4 encounter will see Hill play at blindside flanker and pack down with Aaron Wainwright and Number Eight Ross Moriarty.
Hooker Elliot Dee is also recalled, after his autumn exploits in the international set-up, while lock Matthew Screech is named in the second row alongside Brandon Nansen.
Prop Aaron Jarvis starts against his former team, having played for Clermont between 2016 and 2018, after being named in the front row. Lloyd Fairbrother misses the game through injury.
The one change in the back line is a return for centre Tyler Morgan. Zane Kirchner is named at full back while Adam Warren and Hallam Amos move to the wing.
Gerard Ellis could make his first senior appearance this season from the bench where there are also returns for scrum half Rhodri Williams and fit-again fly half Gavin Henson.
Coach Ceri Jones said: “It is a huge challenge away at Clermont, one of the in-form teams in European rugby who boast a strong home record. All the players are looking forward to the test and playing in the Stade Marcel-Michelin.
“We welcome back our Welsh internationals, who will give the team a lift, and the squad is determined to put in a big performance as we look to build momentum before the derby games over the festive period.”